8019/8000, the trimitone comma (for "triple minor (whole) tone"), is the comma in the 184.108.40.206 subgroup by which a stack of three instances of 10/9 fall short of 11/8, thus leading to the formulation of (11/8)/(10/9)3. Furthermore, it is also the interval separating the syntonic comma and the ptolemisma.
In the full 11-limit, tempering it out leads to the rank-4 trimitone temperament (→ Rank-4 temperament #Trimitone).
In terms of microtempering the 220.127.116.11 subgroup, it may combine well with the schisma as doing so gives lower-complexity interpretations to the 5-limit "tritones" of (10/9)3 and (9/8)3 and their octave-complements, which results in the 53&65 (or equivalently 12&53) temperament in the 18.104.22.168 subgroup. (The term "tritones" is being used here in the sense of stacking 3 tones, as calling (10/9)3 a "tritone" is questionable.) For optimising this temperament, 183edo is recommendable, although 65edo provides a less accurate tuning at the benefit of a more manageable number of tones (and at the benefit of being a superset of 5edo and 13edo, thus potentially making it easier to conceptualise). This temperament is therefore great for 8:9:10:11:12 chords. If extended to the full 11- or 13-limit, it is closely related to bischismic, which also tempers 3136/3125.