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281edo is the equal division of the octave into 281 parts of 4.2705 cents each. It tempers out 225/224 in the 7-limit, and 243/242 and 4000/3993 in the 11-limit limit, so that it supports marvo temperament and provides the optimal patent val; it also gives the optimal patent val for the rank three spectacle temperament.

281edo is the 60th prime EDO.